Sycuan offers one of the biggest poker rooms in San Diego featuring 17 poker tables. Mega Quads is back at the Sycuan Poker Room! Qualifying hands win prizes Monday - Sunday from Noon - Midnight, or following Grave Super Yahtzee until 8AM! Sycuan Casino Resort is a Native American casino in El Cajon, California and is open daily 24 hours. Sycuan Casino Resort | followers on LinkedIn. The casino's square foot gaming space features. Join a poker tournament or sit in on a game of Texas Hold'em today. A story luxury hotel tower featuring + guest rooms and a range of onsite amenities. Poker is back and now open 24/7! Guests are required to follow all health and safety protocols while playing and staying with us. Every month at Sycuan, we have a wide variety of casino table games such as casino poker promotions and special. Poker is open 24 hours a day, 7 days a week. sycuan casino buffet. .